Association of body mass index with the development of metabolic acidosis in patients with chronic kidney disease

Aims Higher body mass index (BMI) is associated with higher bone and serves as a buffer during the development of metabolic acidosis. The authors sought to examine relationship between BMI acidosis in patients chronic kidney disease (CKD). Materials Methods study utilized large US longitudinal data repository including over 103 million from healthcare provider organizations evaluate exposure variable prevalence incidence among estimated glomerular filtration rate <60 ml/min/1.73 m2. Incident was identified at first two consecutive post-index serum bicarbonate values, 10–365 days apart, 12 <22 mEq/L normal bicarbonate. Cox proportional hazard models were adjusted for multiple variables demographics, comorbidities, income, education, function. Results 103,766 qualified this study; 6472 (6.2%) had index. An inverse association category observed both baseline (prevalence) new-onset (incidence) Compared 18.5 <25 kg/m2, each incrementally decreasing risk incident acidosis; ratios (95% confidence interval) 0.866 (0.824–0.911), 0.770 (0.729–0.813), 0.664 (0.622–0.709), 0.612 (0.571–0.655) 25 <30, 30 <35, 35 <40, 40+ respectively. Conclusions Among CKD, an incremental increase inversely These associations suggest that increased weight may protect against acidosis, factor progressive loss